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KMID : 0377519970220020077
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Chung-Ang Journal of Medicine
1997 Volume.22 No. 2 p.77 ~ p.85
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Histopathologic Features of Hepatitis C
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Kim Hyung-Joon
Kim Jae-Kyu
Kim Mi-Kyung
Park Joong-Won
Yoo Byung-Chul
Park Sil-Moo
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Abstract
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After the discovery of hepatitis C virus, several reports of histologic charcteristics of hepatitis C have been published. The aim of this study is to evaluate histopathologic features of hepatitis C for diagnostic significance. Needle biopsy specimens obtanied from the liver of 14 patients with hepatitis C were evaluated for the diagnostic significance. All patients had not any evidence of hepatitis B, and autoimmune and alcoholic liver diseases. The specimens were histologically evaluted based on previously reported features of hepatitis C such as bile duct damage, lymphocytes infiltration, steatosis and so on. According to the mode of transmission, sporadic infections were 12 cases, posttransfusion hepatitis and Ⅵ drug abuser was 1 case. The commonst finding was sinusoidal inflammatory cell activation, especially lymphocyte (86%). And lymphoid follicles or lymphocytes aggregates (65%), steatatosis (65%) were found. According to the activity of hepatitis, significant difference of pathologic features could not be proposed, but most histologic features were showned in CAH. In conclusion, all the histologic characteristics of hepatitis C such as sinusoidal cell activation, lymphoid aggregates, steatosis were observed in this study. But the further study of comparative histologic evaluation between hepatitis C and other hepatitis is needed. And also, comparative study with larger subjects for specific histopathologic findings according to the activity of hepatitis and epidemiologic cause in needed.
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KEYWORD
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Hepatitis, HCV, histology
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